Enable RSS Feeds
RSS is designed to deliver the newest content on a site, stripped of graphical elements and other impediments to transmission. It's often the easiest and fastest way to send your content to handhelds. For some websites, enabling RSS may be all you need to do to convert your website for mobile users.
Consider whether or not to go ".mobi"
Companies looking to serve the mobile market should design a version of their sites for these devices, and many argue that implies switching to a ".mobi" domain name. The top-level domain ".mobi" was conceived and launched at a time when many felt the need to separate websites for mobile from standard websites. As a result, a lot of big name advertisers now support sites on the ".mobi" domain.
But with growing technological sophistication, others now argue that ".com" can serve just as well. For example, today it's possible for a server to do a browser detection every time a user hits it and then deliver an appropriate website for each class of device. For what it's worth, however, the W3C says that staying with ".com" for mobile sites breaks the web's convention because not all ".com" sites are suitable for handhelds.
As handhelds evolve from today's 2.5G and 3G into tomorrow's 4G technology, the gap between handheld and desktop user experiences will certainly narrow.