Your resume sucks, and people laugh at you when they look at it. They hold it up in the office, read your feeble accomplishments out loud, and send them as jokes to each other when they feel sad and need a good laugh. Some of them even know you would be the perfect candidate for the job, but they openly mock your unemployment.
That is what many think must be happening when they submit a resume for a job online. There has to be some reason why people are not calling back...doesn't there? And yet, like an ever-replicating zombie-clone beating its head against a wall trying to get through, you continue to submit that resume again, and again, and again, with no response. Not even an email acknowledgment that you exist other than as an "applicant" who they will get back to "if there is a good fit." And yet, even though you know you are a good fit for the role (and many others you have applied to), there is no reply. Only the deafening silence of non-response.
Could it possibly be your resume? One word answer: "Yes, it most absolutely, positively, without question, is your resume, you moronic clod." OK, that's 13 words.